Povezanost između statusa vitamina D, suplementacije vitaminom D, izlaganja sunčevoj svjetlosti i Parkinsonove bolesti: sistematski pregled i meta-analiza.
Medical science monitor : international medical journal of experimental and clinical research
Sažetak istraživanja
POZADINA Ovaj pregled literature i meta-analiza imali su za cilj da utvrde povezanost između nedostatka vitamina D ili 25-hidroksivitamina D i Parkinsonove bolesti, te da li vitamin D iz suplemenata i sunčeve svjetlosti poboljšava simptome Parkinsonove bolesti. MATERIJAL I METODE Pregled literature i meta-analiza obavljeni su u skladu sa Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sistematski pregled literature obavljen je korištenjem baza podataka koje su uključivale Web of Science, PubMed, Cochrane biblioteku i Embase. Za procjenu kvaliteta studija korištene su Jadad skala (Oxfordski sistem bodovanja kvaliteta) i Newcastle-Ottawa skala (NOS). REZULTATI U metaanalizu je uključeno osam studija. I insuficijencija 25-hidroksivitamina D (<30 ng/mL) (OR, 1,77; 95% CI, 1,29-2,43; P<0,001) i nedostatak (<20 ng/mL) (OR, 2,55; 95% CI, 1,270 značajno su povećani sa P<.3, 1,27; rizik od Parkinsonove bolesti u poređenju sa normalnim kontrolama Izlaganje sunčevoj svetlosti (³15 min/sedmično) je značajno povezano sa smanjenim rizikom od Parkinsonove bolesti (OR, 0,02; 95% CI, 0,00-0,10; P<0,001). Upotreba suplemenata vitamina D bila je efikasna u povećanju nivoa 25-hidroksivitamina D (SMD, 1,79; 95% CI, 1,40-2,18; P<0,001), ali nije imala značajan uticaj na motoričku funkciju (MD, -1,82; 95% CI, -5,10-1,45; P=0) kod pacijenata sa Parkovom bolešću. ZAKLJUČCI Nedostatak i nedostatak 25-hidroksivitamina D i smanjeno izlaganje sunčevoj svjetlosti značajno su povezani sa povećanim rizikom od Parkinsonove bolesti. Međutim, dodaci vitamina D nisu rezultirali značajnim prednostima u poboljšanju motoričke funkcije kod pacijenata sa Parkinsonovom bolešću.
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The Association Between Vitamin D Status, Vitamin D Supplementation, Sunlight Exposure, and Parkinson's Disease: A Systematic Review and Meta-Analysis.
BACKGROUND This literature review and meta-analysis aimed to determine the association between deficiency of vitamin D, or 25-hydroxyvitamin D, and Parkinson's disease, and whether vitamin D from supplements and sunlight improves the symptoms of Parkinson's disease. MATERIAL AND METHODS A literature review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Systematic literature review was performed using databases that included the Web of Science, PubMed, the Cochrane Library, and Embase. The Jadad scale (the Oxford quality scoring system) and the Newcastle-Ottawa scale (NOS) were used to evaluate the quality of the studies. RESULTS Eight studies were included in the meta-analysis. Both 25-hydroxyvitamin D insufficiency (<30 ng/mL) (OR, 1.77; 95% CI, 1.29-2.43; P<0.001) and deficiency (<20 ng/mL) (OR, 2.55; 95% CI, 1.98-3.27; P<0.001) were significantly associated with an increased risk of Parkinson's disease when compared with normal controls Sunlight exposure (³15 min/week) was significantly associated with a reduced risk of Parkinson's disease (OR, 0.02; 95% CI, 0.00-0.10; P<0.001). The use of vitamin D supplements was effective in increasing 25-hydroxyvitamin D levels (SMD, 1.79; 95% CI, 1.40-2.18; P<0.001), but had no significant effect on motor function (MD, -1.82; 95% CI, -5.10-1.45; P=0.275) in patients with Parkinson's disease. CONCLUSIONS Insufficiency and deficiency of 25-hydroxyvitamin D and reduced exposure to sunlight were significantly associated with an increased risk of Parkinson's disease. However, vitamin D supplements resulted in no significant benefits in improving motor function for patients with Parkinson's disease.
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- DOI
- 10.12659/msm.912840
- PMID
- 30672512
- PMCID
- PMC6352758
- Provjereno
- 2026-07-26
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