Sistematski pregled fotodinamičke terapije kao antivirusnog tretmana: Potencijalni vodič za suočavanje sa SARS-CoV-2.
Photodiagnosis and photodynamic therapy
Sažetak istraživanja
Pozadina SARS-CoV-2, koji uzrokuje bolest koronavirusa (COVID-19), predstavlja visoke stope morbiditeta i smrtnosti širom svijeta. Potraga za eliminacijom SARS-CoV-2 je u toku i hitna. Ovaj sistematski pregled nastoji da proceni da li fotodinamička terapija (PDT) može biti efikasna u inaktivaciji SARS-CoV-2.
Metode Pitanje u fokusu je bilo: Može li se fotodinamička terapija koristiti kao potencijalna smjernica za suočavanje sa SARS-CoV-2?". Pretraživanje literature, prema izjavama PRISMA-e, obavljeno je u elektronskim bazama podataka PubMed, EMBASE, SCOPUS, Web of Science, LILACS i Google Scholar. Studije objavljene od januara 2004. do juna 2004. godine i analizirane su studije In vitro koje su analizirane 20. Učinak PDT-a na viruse sa omotačem i DNK.
Rezultati Od 27 odabranih rukopisa, 24 su bile isključivo in vitro, a dvije su bile in vitro/in vivo pristranost je analizirana u svim studijama.
Zaključak In vitro i in vivo studije odabrane u ovom sistematskom pregledu pokazale su da je PDT sposoban fotoinaktivirati DNK i RNK viruse bez ovojnice, sugerirajući da PDT može potencijalno fotoinaktivirati SARS-CoV-2.
Prikaži originalni naslov i sažetak na engleskom
A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2.
Background SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation.
Methods The focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?". A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses.
Results From 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro, and two had in vitro/in vivo parts. Only one analyzed publication was exclusively in vivo. Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies.
Conclusion The in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.
Izvorni podaci
- DOI
- 10.1016/j.pdpdt.2021.102221
- PMID
- 33601001
- PMCID
- PMC7883714
- Provjereno
- 2026-07-26
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