Povezanost omjera cifara (2D : 4D) s rakom: sistematski pregled i meta-analiza.
Disease markers
Sažetak istraživanja
Cilj Intrauterino okruženje polnih hormona kao što je naznačeno omjerom druge i četvrte cifre (2D : 4D) može biti povezano s rizikom od raka. Ovaj sistematski pregled i meta-analiza imali su za cilj procjenu povezanosti 2D : 4D s dijagnozom raka, malignitetom i dobi u trenutku prezentacije.
Metode Studije koje su procjenjivale povezanost 2D : 4D s rizikom od raka prikupljene su iz Pubmed/MEDLINE i Clarivate Analytics baza podataka. U kvalitativnu analizu uključeno je devetnaest studija.
Rezultati Odnos 2D : 4D proučavan je kod raka prostate, raka dojke, raka testisa, raka želuca, raka usne šupljine, tumora mozga i cervikalne intraepitelne neoplazije. Nizak 2D : 4D bio je povezan s rakom prostate, karcinomom želuca i tumorima mozga, dok je visok 2D : 4D bio povezan s rizikom od raka dojke i cervikalne displazije. Odnos 2D : 4D nije povezan sa stadijumom raka prostate, dojke i želuca. Veći omjer 2D : 4D bio je povezan s mlađom prezentacijom raka dojke i tumora mozga. Meta-analize su pokazale da karcinom testisa nije bio povezan sa omjerom 2D : 4D desne ruke (p = 0,74), a rak želuca nije bio povezan s omjerom desne (p = 0,15) i lijeve ruke (p = 0,95) 2D : 4D.
Zaključci Okruženje polnih hormona tokom ranog razvoja povezano je sa rizikom od raka kasnije u životu. Podstiču se dalje studije koje istražuju vezu između intrauterinog hormonskog okruženja i rizika od raka.
Prikaži originalni naslov i sažetak na engleskom
The Association of Digit Ratio (2D : 4D) with Cancer: A Systematic Review and Meta-Analysis.
Objective Intrauterine sex hormone environment as indicated by the second to the fourth digit ratio (2D : 4D) can be associated with cancer risk. This systematic review and meta-analysis aimed to evaluate the association of 2D : 4D with cancer diagnosis, malignancy, and age at presentation.
Methods Studies that evaluated the association of 2D : 4D with cancer risk were collected from Pubmed/MEDLINE and Clarivate Analytics databases. Nineteen studies were included in the qualitative analysis.
Results The 2D : 4D ratio was studied in prostate cancer, breast cancer, testicular cancer, gastric cancer, oral cancer, brain tumors, and cervical intraepithelial neoplasia. Low 2D : 4D was associated with prostate cancer, gastric cancer, and brain tumors, while high 2D : 4D, with breast cancer risk and cervical dysplasia. The 2D : 4D ratio was not associated with prostate, breast, and gastric cancer stage. Greater 2D : 4D ratio was associated with younger presentation of breast cancer and brain tumors. The meta-analyses demonstrated that testicular cancer was not associated with right-hand 2D : 4D ratio ( p = 0.74) and gastric cancer was not associated with right-hand ( p = 0.15) and left-hand ( p = 0.95) 2D : 4D ratio.
Conclusions Sex hormone environment during early development is associated with cancer risk later in life. Further studies exploring the link between intrauterine hormone environment and cancer risk are encouraged.
Izvorni podaci
- DOI
- 10.1155/2018/7698193
- PMID
- 29581795
- PMCID
- PMC5822871
- Provjereno
- 2026-07-26
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