Utjecaj slabosti na ishode COVID-19: sistematski pregled i meta-analiza 16 kohortnih studija.
The journal of nutrition, health & aging
Sažetak istraživanja
Pozadina Slabi pacijenti su sve podložniji stresu, što se uglavnom manifestuje smanjenom fiziološkom rezervom u metaboličkom i imunološkom sistemu i neuromuskularnom sistemu. Nekoliko studija je otkrilo značajnu povezanost slabosti s ozbiljnošću COVID-19 kako bi se podržali dokazi za primjenu procjene slabosti. Međutim, u drugim studijama bilo je kontradiktornih rezultata. Stoga smo sproveli sistematski pregled i meta-analizu kako bismo sintetizirali trenutne studije kako bismo istražili utjecaj slabosti na ishode COVID-19 i pružili odluke zasnovane na dokazima u kliničkoj praksi.
Cilj Cilj nam je bio da sintetiziramo trenutne studije kako bismo istražili utjecaj slabosti na ishode COVID-19 i pružili odluke zasnovane na dokazima u kliničkoj praksi.
Dizajn Sistematski pregled i meta-analiza 16 kohortnih studija. Učesnici Pacijenti sa COVID-19.
Metode Sistematsko pronalaženje potencijalne literature sprovedeno je u nekoliko javnih elektronskih baza podataka, uključujući Medline (OvidSP), EMBASE, Pubmed i kineske baze podataka (China National Knowledge Infrastructure, Wanfang i Weipu) 1. avgusta 2020. Istraživanje literature je ažurirano 26. oktobra 2020. godine. Za procenu kvaliteta u Ottahoru korišćen je S. Newcastle. RevMan (verzija 5.3) i Stata 14.0 su korišteni za sintetizaciju združenih efekata.
Rezultati Prema unapred definisanim kriterijumima za uključivanje i isključivanje, u finalnu analizu je uključeno šesnaest studija od 4324 pacijenta. Slabost je bila značajno povezana s povećanim rizikom smrtnosti od svih uzroka među pacijentima s COVID-19, sa združenim prilagođenim omjerom šansi od 1,81 (95% intervali povjerenja: 1,48, 2,21, I2=87,0%, P
Zaključci U ovoj meta-analizi, otkrili smo da je slabost značajno povezana s štetnim događajima, povećanim rizikom od pojave bolesti COVID-19 i na odjelu intenzivne njege, primjena invazivne mehaničke ventilacije, dugotrajan boravak s obzirom na epidemiju COVID-19 i nedostatak medicinskih resursa, obraćanje više pažnje na slabost u skriningu doprinijelo bi upravljanju bolesti i raspodjeli resursa među pacijentima s COVID-19.
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The Impact of Frailty on COVID-19 Outcomes: A Systematic Review and Meta-analysis of 16 Cohort Studies.
Background Frail patients are increasingly vulnerable to stress, which is mainly manifested by a reduced physiologic reserve in metabolic and immune systems and neuromuscular system. Several studies found a significant association of frailty with COVID-19 severity to support the evidence for the application of frailty assessment. However, there were contradictory results in other studies. Thus we conducted a systematic review and meta-analysis to synthesize the current studies to investigate impact of frailty on COVID-19 outcomes and provide evidence-based decisions in clinical practice.
Objective We aimed to synthesize the current studies to investigate impact of frailty on COVID-19 outcomes and provide evidence-based decisions in clinical practice.
Design A systematic review and Meta-analysis of 16 cohort studies. Participants Patients with COVID-19.
Methods A systematic retrieving for potential literature was conducted in several public electronic databases, including Medline(OvidSP), EMBASE, Pubmed and Chinese databases(China National Knowledge Infrastructure,Wanfang and Weipu) on August 1, 2020.The literature research was updated on October 26, 2020. Newcastle Ottawa Scale for cohort studies was used for quality assessment. RevMan (Version 5.3) and Stata 14.0 were used to synthesize the pooled effects.
Results According to the predefined inclusion and exclusion criteria, sixteen studies of 4324 patients were included in the final analysis. Frailty was significantly associated with increased risk of all-cause mortality among patients with COVID-19, with pooled adjusted odds ratios of 1.81 (95% confidence intervals:1.48,2.21, I2=87.0%, P
Conclusions In this meta-analysis, we found frailty was significantly associated with an increased risk of clinical adverse events (all- cause mortality, COVID-19 severity, admission to the intensive care unit, application of invasive mechanical ventilation, long-length stay). Given the epidemic of COVID-19 and shortage of medical resources, paying more attention to screening frailty would contribute to disease management and resource allocation among patients with COVID-19.
Izvorni podaci
- DOI
- 10.1007/s12603-021-1611-9
- PMID
- 33949641
- PMCID
- PMC7933604
- Provjereno
- 2026-07-26
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