Status vitamina D i SARS-CoV-2 infekcija i klinički ishodi COVID-19.
Frontiers in public health
Sažetak istraživanja
Pozadina: Nekoliko studija sugerira povezanost između serumskog 25-hidroksivitamina D (25OHD) i ishoda infekcije virusom korona-2 (SARS-CoV-2) teškog akutnog respiratornog sindroma, posebno težine i smrtnosti povezanih s bolešću korona virusom-2019 (COVID-19).
Cilj ove meta-analize bio je istražiti je li status vitamina D povezan s težinom COVID-19, definiranom kao ARDS koji zahtijeva prijem na jedinicu intenzivne njege (ICU) ili smrtnošću (primarni krajnji ciljevi) i s osjetljivošću na SARS-CoV-2 i hospitalizaciju povezanu s COVID-19 (sekundarne krajnje točke). Metode: Pretraživanje u PubMed-u, ScienceDirect-u, Web of Science-u, Google Scholar-u, Scopusu i repozitorijumima preprinta obavljeno je do 31. marta 2021. kako bi se identificirale sve originalne opservacijske studije koje izvještavaju o mjerama povezanosti, ili dovoljno podataka za njihovo izračunavanje, između statusa vitamina D (nalazi o nedostatku: Pedeset četiri kao-štampane studije su uključene kao potpuni otisak za javno štampanje i 49 studija). Od 1.403.715 osoba je prijavljena povezanost između statusa vitamina D i infekcije SARS-CoV2, hospitalizacije u vezi sa COVID-19 i mortaliteta vezanog za COVID-19 u 17, 9, 27 i 35 studija, respektivno. 95% intervali pouzdanosti [95%CIs]: 2,63, 1,45-4,77; 1,26-2,69; 4,15, 1,76-9,77, respektivno), infekcija SARS-CoV-2 (OR, 95% CI: 1,68, 1,32-2,13; 1,83, 1,43-2,33; 1,49, 1,19, respektivno, 1,19, OR1). 95% CI 2,51, 1,63-3,85 2,38, 1,56-3,63 Uzimajući u obzir specifične podgrupe (tj. bijelci, studije visokog kvaliteta i studije koje su izvještavale o niskim razinama vitamina D); povećan rizik od ARDS-a koji zahtijeva prijem u jedinicu intenzivne njege (ICU) ili mortaliteta zbog infekcije SARS-CoV-2 i veće osjetljivosti na infekciju SARS-CoV-2 i povezane hospitalizacije.
Prikaži originalni naslov i sažetak na engleskom
Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes.
Background: Several studies suggest an association between serum 25-hydroxyvitamin D (25OHD) and the outcomes of Severe Acute Respiratory Syndrome Corona-Virus-2 (SARS-CoV-2) infection, in particular Coronavirus Disease-2019 (COVID-19) related severity and mortality. The aim of the present meta-analysis was to investigate whether vitamin D status is associated with the COVID-19 severity, defined as ARDS requiring admission to intensive care unit (ICU) or mortality (primary endpoints) and with the susceptibility to SARS-CoV-2 and COVID-19-related hospitalization (secondary endpoints). Methods: A search in PubMed, ScienceDirect, Web of Science, Google Scholar, Scopus, and preprints repositories was performed until March 31th 2021 to identify all original observational studies reporting association measures, or enough data to calculate them, between Vitamin D status (insufficiency Findings: Fifty-four studies (49 as fully-printed and 5 as pre-print publications) were included for a total of 1,403,715 individuals. The association between vitamin D status and SARS-CoV2 infection, COVID-19 related hospitalization, COVID-19 related ICU admission, and COVID-19 related mortality was reported in 17, 9, 27, and 35 studies, respectively. Severe deficiency, deficiency and insufficiency of vitamin D were all associated with ICU admission (odds ratio [OR], 95% confidence intervals [95%CIs]: 2.63, 1.45-4.77; 2.16, 1.43-3.26; 2.83, 1.74-4.61, respectively), mortality (OR, 95%CIs: 2.60, 1.93-3.49; 1.84, 1.26-2.69; 4.15, 1.76-9.77, respectively), SARS-CoV-2 infection (OR, 95%CIs: 1.68, 1.32-2.13; 1.83, 1.43-2.33; 1.49, 1.16-1.91, respectively) and COVID-19 hospitalization (OR, 95%CIs 2.51, 1.63-3.85; 2.38, 1.56-3.63; 1.82, 1.43-2.33). Considering specific subgroups (i.e., Caucasian patients, high quality studies, and studies reporting adjusted association estimates) the results of primary endpoints did not change. Interpretations: Patients with low vitamin D levels present an increased risk of ARDS requiring admission to intensive care unit (ICU) or mortality due to SARS-CoV-2 infection and a higher susceptibility to SARS-CoV-2 infection and related hospitalization.
Izvorni podaci
- DOI
- 10.3389/fpubh.2021.736665
- PMID
- 35004568
- PMCID
- PMC8727532
- Provjereno
- 2026-07-26
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