Arbovirusi koji se prenose transfuzijom: ažuriranje i sistematski pregled.
PLoS neglected tropical diseases
Sažetak istraživanja
Pozadina Otkrivanje prvih slučajeva virusa Zapadnog Nila prenošenog transfuzijom 2002. godine predstavljalo je novi izazov za sigurnost transfuzije. Institucije poput Svjetske zdravstvene organizacije navele su da centri za transfuziju krvi moraju znati epidemiologiju različitih infektivnih agenasa u nastajanju i njihov utjecaj na transfuziju krvi.
Cilj rada je sagledati objavljene slučajeve prenošenja arbovirusa transfuzijom krvi ili krvnih komponenti i analizirati njihove glavne kliničke i epidemiološke karakteristike. Materijal i metode Sistematske pretrage literature vršene su u MEDLINE-u, Embase-u i Scopusu. Parovi autora pregleda odabrali su različite naučne publikacije koje izvještavaju o slučajevima arbovirusa koji se prenose transfuzijom. Pregledane su glavne kliničke i epidemiološke karakteristike opisanih slučajeva. Protokol studije je registrovan u PROSPERO CRD42021270355.
Rezultati Identificirana su 74 slučaja infekcija koje se prenose transfuzijom od 10 arbovirusa: virus Zapadnog Nila (n = 42), virus denga (n = 18), virus Zika (n = 3), virus vakcine protiv žute groznice (n = 3), virus encefalitisa koji se prenosi krpeljima (n = 2 virusa japanskog encefalitisa (n = 2), virus Powan 1), virus encefalitisa St. Louisa (n = 1), virus Ross River (n = 1) i virus krpeljne groznice Colorado (n = 1). Krvna komponenta koja je najčešće uključena bila su crvena krvna zrnca (N = 35, 47,3%; 95% interval pouzdanosti [CI] 35,9% do 58,7%). U 54,1% (N = 40; 95% CI: 42,7%-65,47%) slučajeva, primalac je bio imunosupresivan. Prenos je rezultirao smrću kod 18,9% (N = 14; 95% CI: 10,0%-27,8%) primalaca. Osim toga, identificirano je 18 dodatnih arbovirusa s potencijalnom prijetnjom sigurnosti transfuzije. Diskusija U posljednjih 20 godina, broj objavljenih slučajeva arbovirusa koji se prenose transfuzijom značajno se povećao, što implicira nove arboviruse. Osim toga, otkriven je značajan broj arbovirusa koji mogu predstavljati prijetnju sigurnosti transfuzije. Očekuje se da će se u narednim godinama prijenos arbovirusa nastaviti globalno širiti. Stoga je neophodno da se sve odgovorne agencije pripreme za ovu potencijalnu prijetnju sigurnosti transfuzije.
Prikaži originalni naslov i sažetak na engleskom
Transfusion-transmitted arboviruses: Update and systematic review.
Background The detection of the first cases of transfusion-transmitted West Nile virus in 2002 posed a new challenge for transfusion safety. Institutions like the World Health Organization have stated that blood transfusion centers need to know the epidemiology of the different emerging infectious agents and their impact on blood transfusion. The aim of the study is to review the published cases of arbovirus transmission through transfusion of blood or blood components and to analyze their main clinical and epidemiological characteristics. Material and methods Systematic literature searches were conducted in MEDLINE, Embase and Scopus. Pairs of review authors selected a variety of scientific publications reporting cases of transfusion-transmitted arboviruses. Main clinical and epidemiological characteristics were reviewed of the cases described. The study protocol was registered in PROSPERO CRD42021270355.
Results A total of 74 cases of transfusion-transmitted infections were identified from 10 arboviruses: West Nile virus (n = 42), dengue virus (n = 18), Zika virus (n = 3), yellow fever vaccine virus (n = 3), tick-borne encephalitis virus (n = 2), Japanese encephalitis virus (n = 2), Powassan virus (n = 1), St. Louis encephalitis virus (n = 1), Ross River virus (n = 1) and Colorado tick fever virus (n = 1). The blood component most commonly involved was red blood cells (N = 35, 47.3%; 95% confidence interval [CI] 35.9% to 58.7%). In 54.1% (N = 40; 95% CI: 42.7%-65.47%) of the cases, the recipient was immunosuppressed. Transmission resulted in death in 18.9% (N = 14; 95% CI: 10.0%-27.8%) of the recipients. In addition, 18 additional arboviruses were identified with a potential threat to transfusion safety. Discussion In the last 20 years, the number of published cases of transfusion-transmitted arboviruses increased notably, implicating new arboviruses. In addition, a significant number of arboviruses that may pose a threat to transfusion safety were detected. In the coming years, it is expected that transmission of arboviruses will continue to expand globally. It is therefore essential that all responsible agencies prepare for this potential threat to transfusion safety.
Izvorni podaci
- DOI
- 10.1371/journal.pntd.0010843
- PMID
- 36201547
- PMCID
- PMC9578600
- Provjereno
- 2026-07-26
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