Povezanost između biljnih obrazaca ishrane i rizika od dijabetesa tipa 2, kardiovaskularnih bolesti, raka i smrtnosti – sistematski pregled i meta-analiza.
Nutrition journal
Sažetak istraživanja
Pozadina Obrasci ishrane zasnovani na biljci dobijaju više pažnje zbog svog potencijala u smanjenju rizika od razvoja velikih hroničnih bolesti, uključujući dijabetes tipa 2 (T2D), kardiovaskularne bolesti (KVB), rak i smrtnost, dok nedostaje ažuran sveobuhvatan kvantitativni pregled. Ova studija imala je za cilj da sumira postojeće prospektivne opservacijske dokaze o povezanosti pridržavanja biljnih obrazaca ishrane i ishoda kroničnih bolesti.
Metode Proveli smo sistematski pregled i meta-analizu dokaza u prospektivnim opservacijskim studijama. Korišteni izvori podataka su PubMed i MEDLINE, Embase, Web of Science i skrining referenci. Uključili smo sve prospektivne opservacijske studije koje su procjenjivale povezanost između pridržavanja biljnih obrazaca ishrane i incidencije T2D, KVB, raka i mortaliteta kod odraslih (≥ 18 godina).
Rezultati Ukupno je identifikovano 76 publikacija, uključujući 2.230.443 učesnika sa 60.718 slučajeva incidenata T2D, 157.335 slučajeva KVB, 57.759 slučajeva raka i 174.435 smrtnih slučajeva. Uočena je inverzna povezanost između veće pridržavanja biljnog obrasca ishrane i rizika od T2D (RR, 0,82 [95% CI: 0,77-0,86]), KVB (0,90 [0,85-0,94]), karcinoma (0,91 [0,87-0,96]) i smrtnosti od svih uzroka (0,48). [0,78-0,92]) sa umjerenom do visokom heterogenošću kroz studije (I 2 se kretao: 47,8-95,4%). Inverzne asocijacije sa T2D, KVB i rakom su ojačane kada su zdrave biljne namirnice, kao što su povrće, voće, integralne žitarice i mahunarke, bile naglašene u definiciji biljnog načina ishrane (T2D: 0,79 [0,72-0,87]; CVD: 0,80-0,6:0,8] rak; [0,80-0,92] I 2 se kretao: 53,1-84,1%). Povezanost mortaliteta bila je uglavnom slična kada su analize bile ograničene na zdravu biljnu ishranu (0,86 [0,80-0,92], I 2 = 91,9%). Nasuprot tome, nezdrava biljna prehrana bila je pozitivno povezana s ovim ishodima bolesti. Među četiri studije koje su ispitivale promene u obrascima ishrane, povećano pridržavanje biljnih obrazaca ishrane bilo je povezano sa značajno smanjenim rizikom od T2D (0,83 [0,71-0,96]; I 2 = 71,5%) i neznatno nižim rizikom od smrtnosti (0,95 [0,91-1,00]%); I.2.
Zaključci Bolje pridržavanje biljnih obrazaca ishrane, posebno onih koji naglašavaju zdravu biljnu hranu, korisno je za smanjenje rizika od velikih hroničnih stanja, uključujući T2D, KVB, rak, kao i preranu smrt. Registracija protokola revizije Ova recenzija je registrovana u PROSPERO International Prospective Register of Systematic Reviews (https://www.crd.york.ac.uk/PROSPERO/) pod registracijskim brojem CRD42022290202.
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Associations between plant-based dietary patterns and risks of type 2 diabetes, cardiovascular disease, cancer, and mortality - a systematic review and meta-analysis.
Background Plant-based dietary patterns are gaining more attention due to their potential in reducing the risk of developing major chronic diseases, including type 2 diabetes (T2D), cardiovascular disease (CVD), cancer, and mortality, while an up-to-date comprehensive quantitative review is lacking. This study aimed to summarize the existing prospective observational evidence on associations between adherence to plant-based dietary patterns and chronic disease outcomes.
Methods We conducted a systematic review and meta-analysis of evidence across prospective observational studies. The data sources used were PubMed and MEDLINE, Embase, Web of Science, and screening of references. We included all prospective observational studies that evaluated the association between adherence to plant-based dietary patterns and incidence of T2D, CVD, cancer, and mortality among adults (≥ 18 years).
Results A total of 76 publications were identified, including 2,230,443 participants with 60,718 cases of incident T2D, 157,335 CVD cases, 57,759 cancer cases, and 174,435 deaths. An inverse association was observed between higher adherence to a plant-based dietary pattern and risks of T2D (RR, 0.82 [95% CI: 0.77-0.86]), CVD (0.90 [0.85-0.94]), cancer (0.91 [0.87-0.96]), and all-cause mortality (0.84 [0.78-0.92]) with moderate to high heterogeneity across studies (I 2 ranged: 47.8-95.4%). The inverse associations with T2D, CVD and cancer were strengthened when healthy plant-based foods, such as vegetables, fruits, whole grains, and legumes, were emphasized in the definition of plant-based dietary patterns (T2D: 0.79 [0.72-0.87]; CVD: 0.85 [0.80-0.92]; cancer: 0.86 [0.80-0.92]; I 2 ranged: 53.1-84.1%). Association for mortality was largely similar when the analyses were restricted to healthy plant-based diets (0.86 [0.80-0.92], I 2 = 91.9%). In contrast, unhealthy plant-based diets were positively associated with these disease outcomes. Among four studies that examined changes in dietary patterns, increased adherence to plant-based dietary patterns was associated with a significantly reduced risk of T2D (0.83 [0.71-0.96]; I 2 = 71.5%) and a marginally lower risk of mortality (0.95 [0.91-1.00]; I 2 = 0%).
Conclusions Better adherence to plant-based dietary patterns, especially those emphasizing healthy plant-based foods, is beneficial for lowering the risks of major chronic conditions, including T2D, CVD, cancer, as well as premature deaths. Registration of review protocol This review was registered at the PROSPERO International Prospective Register of Systematic Reviews ( https://www.crd.york.ac.uk/PROSPERO/ ) with the registration number CRD42022290202.
Izvorni podaci
- DOI
- 10.1186/s12937-023-00877-2
- PMID
- 37789346
- PMCID
- PMC10548756
- Provjereno
- 2026-07-26
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