Suplementacija gvožđa kod nedonoščadi i novorođenčadi sa malom porođajnom težinom: sistematski pregled interventnih studija.
Nutrition reviews
Sažetak istraživanja
Kontekst Preporučuje se enteralna suplementacija gvožđem kod nedonoščadi kako bi se obezbedilo dovoljno gvožđa za rast i razvoj bez povećanja rizika od preopterećenja gvožđem. Međutim, trenutne preporuke datiraju iz 2010. godine i zasnovane su na ograničenim dokazima.
Cilj Ovaj sistematski pregled imao je za cilj da istraži efekte enteralne suplementacije gvožđem na status gvožđa, rast, neurološki razvoj i neželjene kliničke ishode kod prevremeno rođenih (Izvori podataka Baza podataka PubMed/Medline i Cochrane biblioteke pretražena je do 31. oktobra 2018. Ekstrakcija podataka Od 684 27 identifikovanih zapisa18. ispitivanja (RCT) plus 4 nerandomizirane intervencije, uočeno je da je kvaliteta studije loša do fer. Rezultati. Među 7 članaka o neurološkom razvoju uočen je pozitivan učinak na ponašanje nakon 3,5 i 7 godina u jednom švedskom RCT-u Nedostatak gvožđa i anemija kod nedonoščadi i LBW-a, međutim, nedostaju visokokvalitetni dokazi o dugoročnim efektima suplementacije na funkcionalne zdravstvene ishode. Potrebni su dobro osmišljeni, dugotrajni RCT-ovi s odgovorom na dozu, kako bi se utvrdila optimalna doza i način uzimanja u obzir za dugoročnu ishranu. Registracija sistematskog pregleda PROSPERO br. CRD42018085214.
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Iron supplementation in preterm and low-birth-weight infants: a systematic review of intervention studies.
Context Enteral iron supplementation in preterm infants is recommended to supply sufficient iron for growth and development without increasing the risk of iron overload. However, the current recommendations date from 2010 and are based on limited evidence.
Objective This systematic review aimed to investigate the effects of enteral iron supplementation on iron status, growth, neurological development, and adverse clinical outcomes in preterm ( Data sources The PubMed/Medline and Cochrane Library databases were searched to 31 October 2018. Data extraction Of the 684 records identified, 27 articles, describing 18 randomized controlled trials (RCTs) plus 4 nonrandomized interventions, were included. Using the Cochrane Collaboration's criteria, study quality was found to be poor to fair overall.
Results Most articles (23/27) reported iron status indices; supplementation for ≥8 weeks resulted in increased hemoglobin and ferritin concentrations and a reduction in iron deficiency and anemia. No article reported on iron overload. Growth-related parameters reported in 12 articles were not affected by supplementation. Among the 7 articles on neurological development, a positive effect on behavior at 3.5 and 7 years was observed in one Swedish RCT. No association was found between supplementation and adverse clinical outcomes in the 9 articles reporting on studies in which such data was collected.
Conclusions Long-term iron supplementation appears to result in improved iron status and a reduction in iron deficiency and anemia in preterm and LBW infants. However, high-quality evidence regarding the long-term effects of supplementation on functional health outcomes is lacking. Iron overload has largely been ignored. Well-designed, long-term, dose-response RCTs are required to ascertain the optimal dose and delivery method for the provision of dietary iron in preterm infants, with consideration of short- and long-term health effects. Systematic review registration PROSPERO registration no. CRD42018085214.
Izvorni podaci
- DOI
- 10.1093/nutrit/nuz051
- PMID
- 31532494
- PMCID
- PMC6888764
- Provjereno
- 2026-07-26
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