Efekti akupunkture na ishod trudnoće vantjelesne oplodnje: sistematski pregled i meta-analiza.
BMC complementary and alternative medicine
Sažetak istraživanja
Pozadina Efekti akupunkture na ishode vantelesne oplodnje (IVF) ostaju kontroverzni. A varijacije u učesnicima, intervencijama, proučavanim ishodima i dizajnu ispitivanja mogu se odnositi na efikasnost adjuvantne akupunkture.
Metode Pretražili smo digitalne baze podataka za relevantne studije, uključujući Embase, PubMed, Cochrane biblioteku i neke kineske baze podataka do decembra 2018. godine, za randomizirana kontrolirana ispitivanja (RCT) koja procjenjuju efekte akupunkture na žene koje su podvrgnute IVF-u. Uključili smo studije s intervencijskim grupama koje su koristile ubod igle i kontrolne grupe koje se sastoje od bez akupunkture ili lažne (placebo) akupunkture. Primarni ishodi bili su klinička stopa trudnoće (CPR) i stopa živorođenih (LBR). Meta-regresija i analiza podgrupa su sprovedene na osnovu osam unapred specificiranih kovarijata da bi se istražile varijanse efekata adjuvantne akupunkture na stope trudnoće i izvore heterogenosti.
Rezultati Uključeno je dvadeset sedam studija sa 6116 učesnika. Objedinjena stopa kliničke trudnoće (CPR) iz svih akupunkturnih grupa bila je značajno veća od one u kontrolnim grupama (RR 1,21, 95% CI: 1,07-1,38), dok objedinjena stopa živorođenih (LBR) nije bila. Meta-regresiona analiza podgrupa pokazala je značajniju korist od akupunkture za proporciju ponovljenih IVF ciklusa (broj žena sa istorijom prethodnog neuspešnog pokušaja IVF-a podeljen brojem žena uključenih u svako ispitivanje) ≥ 50% grupa (CPR: RR 1,60, 95% CI: 1,28-2:0%; RR: 1,28-2:0. 1,05-1,92), a ova kovarijanta je objasnila većinu heterogenosti (CPR i LBR: prilagođeni R 2 = 100 i 87,90%). Slični rezultati su pronađeni između CPR-a i broja tretmana akupunkturom (CPR: p = 0,002, prilagođeni R 2 = 51,90%), ali ne i LBR.
Zaključci Naša analiza otkriva korist od akupunkture za ishode IVF-a kod žena sa istorijom neuspešnog pokušaja IVF-a, a broj tretmana akupunkturom je potencijalni uticajni faktor. S obzirom na loše izvještavanje i metodološke nedostatke postojećih studija, potrebne su studije većeg obima i bolje metodologije da bi se ovi nalazi potvrdili.
Prikaži originalni naslov i sažetak na engleskom
The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis.
Background The effects of acupuncture on in vitro fertilization (IVF) outcomes remain controversial. And the variation in participant, interventions, outcomes studied, and trial design may relate to the efficacy of adjuvant acupuncture.
Methods We searched digital databases for relevant studies, including Embase, PubMed, Cochrane Library and some Chinese databases up to December 2018, for randomized controlled trials (RCTs) evaluating the effects of acupuncture on women undergoing IVF. We included studies with intervention groups using needling, and control groups consisting of no acupuncture or sham (placebo) acupuncture. Primary outcomes were clinical pregnancy rate (CPR) and live birth rate (LBR). Meta-regression and subgroup analysis were conducted on the basis of eight pre-specified covariates to investigate the variances of the effects of adjuvant acupuncture on pregnancy rates and the sources of heterogeneity.
Results Twenty-seven studies with 6116 participants were included. The pooled clinical pregnancy rate (CPR) from all of acupuncture groups was significantly greater than that of control groups (RR 1.21, 95% CI: 1.07-1.38), whereas the pooled live birth rate (LBR) was not. Meta-regression subgroup analysis showed a more significant benefit of acupuncture for repeated IVF cycle proportion (number of women with a history of prior unsuccessful IVF attempt divided by number of women included in each trial) ≥ 50% group (CPR: RR 1.60, 95% CI: 1.28-2.00; LBR: RR 1.42, 95% CI: 1.05-1.92), and this covariate explained most of the heterogeneity (CPR and LBR: adjusted R 2 = 100 and 87.90%). Similar results were found between CPR and number of acupuncture treatments (CPR: p = 0.002, adjusted R 2 = 51.90%), but not LBR.
Conclusions Our analysis finds a benefit of acupuncture for IVF outcomes in women with a history of unsuccessful IVF attempt, and number of acupuncture treatments is a potential influential factor. Given the poor reporting and methodological flaws of existing studies, studies with larger scales and better methodologies are needed to verify these findings.
Izvorni podaci
- DOI
- 10.1186/s12906-019-2523-7
- PMID
- 31200701
- PMCID
- PMC6570865
- Provjereno
- 2026-07-26
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